| Histone deacetylase inhibitor reverses LVH in a mouse model. |
|
| Zee News: The researchers engineered mice with overactive autophagy and induced hypertrophy leading to heart failure. Scientists then gave the mice an HDAC inhibitor known to limit autophagy. "The heart decreased back to near its normal size, and heart function that had previously been declining went back to normal," Hill said. "That is a powerful observation where disease regression, not just disease prevention, was seen." |