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k - r a s + g e n e s + % 2 8 1 9 9 8 % 2 9 + c e l l + + 5 3 % 3 a + 5 4 9 - 5 5 4 % 0 d % 0 a + + + + + + + + 2 + s m i t + v % 2 c + b o o t + a % 2 c + s m i t s + a % 2 c + e t + a l + k r a s + c o d o n + 1 2 + m u t a t i o n s + o c c u r + v e r y + f r e q u e n t l y + i n + p a n c r e a t i c + a d e n o c a r c i n o m a s % 2 8 1 9 8 8 % 2 9 + n a r + + 1 6 % 2 8 1 6 % 2 9 % 3 a + 7 7 7 3 - 7 7 8 2 % 0 d % 0 a + + + + + + + + 3 + z h a n g + c % 2 c + g u o + w % 2 c + w u + j % 2 c + e t + a l + d i f f e r e n t i a l + h i g h - r e s o l u t i o n + m e l t i n g + a n a l y s i s + f o r + t h e + d e t e c t i o n + o f + k - r a s + c o d o n s + 1 2 + a n d + 1 3 + m u t a t i o n s + i n + p a n c r e a t i c + c a n c e r + % 2 8 2 0 1 1 % 2 9 + p a n c r e a s + 4 0 % 2 8 8 % 2 9 % 3 a + 1 2 8 3 - 1 2 8 8 % 0 d % 0 a + % 0 d % 0 a h t t p % 3 a % 2 f % 2 f w w w s a n g e r a c u k % 2 f p e r l % 2 f g e n e t i c s % 2 f c g p % 2 f c o s m i c % 3 f a c t i o n % 3 d b y g e n e % 2 6 l n % 3 d k r a s % 2 6 s t a r t % 3 d 1 % 2 6 e n d % 3 d 1 8 9 % 2 6 c o o r d s % 3 d a a + + + + + + + + + + + + 5 + s e r d y u k + o i % 2 c + b o t e z a t u + i v % 2 c + s h e l e p o v + v p % 2 c + e t + a l + d e t e c t i o n + o f + m u t a n t + k - r a s + s e q u e n c e s + i n + t h e + u r i n e + o f + c a n c e r + p a t i e n t s + % 2 8 2 0 0 1 % 2 9 + b u l l + e x p + b i o l + m e d + 1 3 1 % 2 8 3 % 2 9 % 3 a 2 8 3 - 2 8 4 % 0 d % 0 a + + + + + + + + 6 + s u + y h % 2 c + w a n g + m % 2 c + b r e n n e r + d e % 2 c + e t + a l + h u m a n + u r i n e + c o n t a i n s + s m a l l % 2 c + 1 5 0 + t o + 2 5 0 + n u c l e o t i d e - s i z e d % 2 c + s o l u b l e + d n a + d e r i v e d + f r o m + t h e + c i r c u l a t i o n + a n d + m a y + b e + u s e f u l + i n + t h e + d e t e c t i o n + o f + c o l o r e c t a l + c a n c e r + % 2 8 2 0 0 4 % 2 9 + j + m o l + d i a g n + 6 % 2 8 2 % 2 9 % 3 a 1 0 1 - 1 0 7 % 0 d % 0 a + + + + + + + + 7 + s u + y h % 2 c + w a n g + m % 2 c + a i a m k i t s u m r i t + b % 2 c + e t + a l + d e t e c t i o n + o f + a + k - r a s + m u t a t i o n + i n + u r i n e + o f + p a t i e n t s + w i t h + c o l o r e c t a l + c a n c e r + % 2 8 2 0 0 5 % 2 9 + c a n c e r + b i o m a r k + 1 % 2 8 2 - 3 % 2 9 % 3 a + 1 7 7 - 1 8 2 % 0 d % 0 a + + + + + + + + 8 + s u + y h % 2 c + w a n g + m % 2 c + b r e n n e r + d e % 2 c + e t + a l + d e t e c t i o n + o f + m u t a t e d + k - r a s + d n a + i n + u r i n e % 2 c + p l a s m a % 2 c + a n d + s e r u m + o f + p a t i e n t s + w i t h + c o l o r e c t a l + c a r c i n o m a + o r + a d e n o m a t o u s + p o l y p s + % 2 8 2 0 0 8 % 2 9 + a n n + n + y + a c a d + s c i + 1 1 3 7 % 3 a + 1 9 7 - 2 0 6 % 0 d % 0 a + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + t r o v a g e n e % 2 c + i n c % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a h e a d q u a r t e r e d + i n + s a n + d i e g o % 2 c + c a l i f o r n i a % 2 c + t r o v a g e n e + i s + d e v e l o p i n g + i t s + p a t e n t e d + t e c h n o l o g y + f o r + t h e + d e t e c t i o n + o f + t r a n s r e n a l + d n a + a n d + r n a % 2 c + s h o r t + n u c l e i c + a c i d + f r a g m e n t s % 2 c + o r i g i n a t i n g + f r o m + n o r m a l + a n d + d i s e a s e d + c e l l + d e a t h + t h a t + c r o s s + t h e + k i d n e y + b a r r i e r + a n d + c a n + b e + d e t e c t e d + i n + u r i n e % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a t r o v a g e n e + h a s + a + d o m i n a n t + p a t e n t + p o s i t i o n + a s + i t + r e l a t e s + t o + t r a n s r e n a l + m o l e c u l a r + t e s t i n g + i t + h a s + u s + a n d + e u r o p e a n + p a t e n t + a p p l i c a t i o n s + a n d + i s s u e d + p a t e n t s + t h a t + c o v e r + t e s t i n g + f o r + h p v + a n d + o t h e r + i n f e c t i o u s + d i s e a s e s % 2 c + c a n c e r % 2 c + t r a n s p l a n t a t i o n % 2 c + p r e n a t a l + a n d + g e n e t i c + t e s t i n g + i n + a d d i t i o n % 2 c + i t + o w n s + w o r l d w i d e + r i g h t s + t o + n u c l e o p h o s m i n - 1 + % 2 8 n p m 1 % 2 9 % 2 c + a n + i n f o r m a t i v e + b i o m a r k e r + f o r + a c u t e + m y e l o i d + l e u k e m i a + % 2 8 a m l % 2 9 + a n d + m u t a t i o n s + i n + t h e + s f 3 b 1 + g e n e % 2 c + w h i c h + h a v e + b e e n + s h o w n + t o + b e + a s s o c i a t e d + w i t h + c h e m o t h e r a p y + r e s p o n s e + i n + c l l + % 2 8 c h r o n i c + l y m p h o c y t i c + l e u k e m i a % 2 9 + p a t i e n t s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a c e r t a i n + s t a t e m e n t s + i n + t h i s + p r e s s + r e l e a s e + a r e + f o r w a r d - l o o k i n g + w i t h i n + t h e + m e a n i n g + o f + t h e + p r i v a t e + s e c u r i t i e s + l i t i g a t i o n + r e f o r m + a c t + o f + 1 9 9 5 + t h e s e + s t a t e m e n t s + m a y + b e + i d e n t i f i e d + b y + t h e + u s e + o f + f o r w a r d - 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