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r e s i s t a n t + b l o o d + p r e s s u r e + d e s p i t e + t a k i n g + m u l t i p l e % 0 a a n t i - h y p e r t e n s i v e + m e d i c a t i o n s + r e s u l t s + f r o m + t h e + s y m p l i c i t y + h t n - 1 % 0 a t r i a l + h a v e + s h o w n + s u s t a i n e d + s a f e t y + a n d + e f f e c t i v e n e s s + o f + r e n a l % 0 a d e n e r v a t i o n + w i t h + t h e + s y m p l i c i t y + r e n a l + d e n e r v a t i o n + s y s t e m + o u t + t o + t h r e e % 0 a y e a r s % 2 c + a n d + r e s u l t s + f r o m + t h e + s y m p l i c i t y + h t n - 2 + t r i a l + s h o w e d + s a f e % 2 c + a n d % 0 a s t a t i s t i c a l l y + s i g n i f i c a n t + r e d u c t i o n + o f + b l o o d + p r e s s u r e + % 2 8 - 3 3 + m g + h g % 0 a s y s t o l i c + b l o o d + p r e s s u r e % 2 9 + a t + s i x + m o n t h s + f o l l o w i n g + t h e + p r o c e d u r e + a n d % 0 a s u s t a i n e d + t o + 1 2 + m o n t h s + t h e s e + d a t a + w e r e + r e c e n t l y + p r e s e n t e d + a t + t h e % 0 a a n n u a l + a m e r i c a n + c o l l e g e + o f + c a r d i o l o g y + d u r i n g + a n + o r a l + s e s s i o n % 2 c + w h i c h % 0 a w a s + d e d i c a t e d + t o + r e n a l + d e n e r v a t i o n % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a m e d t r o n i c + i s + l e a d i n g + t h e + d e v e l o p m e n t + o f + r e n a l + d e n e r v a t i o n + i n % 0 a a d d i t i o n + t o + t h e + l i c e n c e + f r o m + h e a l t h + c a n a d a % 2 c + t h e + s i m p l i c i t y + r e n a l % 0 a d e n e r v a t i o n + s y s t e m % 2 8 t m % 2 9 + h a s + r e c e i v e d + e u r o p e % 2 7 s + c e + % 2 8 c o n f o r m i t e % 0 a e u r o p e e n e % 2 9 + m a r k + a n d + a + l i s t i n g + w i t h + a u s t r a l i a % 2 7 s + t h e r a p e u t i c + g o o d s % 0 a a d m i n i s t r a t i o n + % 2 8 t g a % 2 9 + t h e + s y m p l i c i t y + r e n a l + d e n e r v a t i o n + s y s t e m + i s % 0 a u n d e r + i n v e s t i g a t i o n a l + u s e + i n + t h e + u n i t e d + s t a t e s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + t h e + s y m p l i c i t y + h t n - 1 + a n d + h t n - 2 + t r i a l s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a s y m p l i c i t y + h t n - 1 + i s + a + s e r i e s + o f + p i l o t + s t u d i e s + i n v o l v i n g + 1 5 3 + p a t i e n t s % 0 a a t + 1 9 + c e n t e r s + i n + a u s t r a l i a % 2 c + e u r o p e + a n d + t h e + u n i t e d + s t a t e s + s u b j e c t s + i n % 0 a t h e + s y m p l i c i t y + h t n - 1 + t r i a l + m a i n t a i n e d + a n + a v e r a g e + b l o o d + p r e s s u r e % 0 a r e d u c t i o n + o f + - 3 3 % 2 f - 1 9 + m m + h g + a t + 3 6 + m o n t h s + % 2 8 n % 3 d 2 4 % 2 9 + f r o m + b a s e l i n e + % 2 8 p + l e s s % 0 a t h a n + 0 0 0 1 % 2 9 + f o l l o w i n g + t r e a t m e n t + w i t h + t h e + s y m p l i c i t y + r e n a l + d e n e r v a t i o n % 0 a s y s t e m + a n + i n c r e a s i n g + p r o p o r t i o n + o f + p a t i e n t s + w h o + c o m p l e t e d + f o l l o w - u p % 0 a h a d + a t + l e a s t + a + 1 0 + m m + h g + r e d u c t i o n + i n + s y s t o l i c + b l o o d + p r e s s u r e + a t + 6 % 0 a m o n t h s + 7 1 + p e r c e n t + o f + p a t i e n t s + w e r e + c l a s s i f i e d + a s + r e s p o n d e r s % 2 c + w h i c h % 0 a i n c r e a s e d + t o + 1 0 0 + p e r c e n t + a m o n g + t h e + p a t i e n t s + w h o + c o m p l e t e d + t h r e e + y e a r % 0 a f o l l o w - u p + t h e r e + w a s + n o + e v i d e n c e + o f + r e n a l + i m p a i r m e n t % 2 c + n o + p a t i e n t s % 0 a w e r e + h o s p i t a l i z e d + d u e + t o + h y p o t e n s i o n % 2 c + a n d + n o + p r o c e d u r e - r e l a t e d % 0 a s e r i o u s + a d v e r s e + e v e n t s + w e r e + s e e n % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a t h e + s y m p l i c i t y + h t n - 2 + t r i a l + i s + a n + i n t e r n a t i o n a l % 2 c + m u l t i - c e n t e r % 2 c % 0 a p r o s p e c t i v e % 2 c + r a n d o m i z e d % 2 c + c o n t r o l l e d + s t u d y + o f + t h e + s a f e t y + a n d % 0 a e f f e c t i v e n e s s + o f + r e n a l + d e n e r v a t i o n + i n + p a t i e n t s + w i t h % 0 a t r e a t m e n t - r e s i s t a n t + h y p e r t e n s i o n + o n e + h u n d r e d - s i x + % 2 8 1 0 6 % 2 9 + p a t i e n t s + w e r e % 0 a r a n d o m l y + a l l o c a t e d + i n + a + o n e - t o - o n e + r a t i o + t o + u n d e r g o + r e n a l + d e n e r v a t i o n % 0 a w i t h + p r e v i o u s + t r e a t m e n t + o r + t o + m a i n t a i n + p r e v i o u s + t r e a t m e n t + a l o n e % 0 a % 2 8 c o n t r o l + g r o u p % 2 9 + a t + 2 4 + p a r t i c i p a t i n g + c e n t e r s + a t + b a s e l i n e + t h e % 0 a r a n d o m i z e d + t r e a t m e n t + a n d + c o n t r o l + p a t i e n t s + h a d + s i m i l a r + h i g h + b l o o d % 0 a p r e s s u r e s % 3 a + 1 7 8 % 2 f 9 7 + m m + h g + a n d + 1 7 8 % 2 f 9 8 + m m + h g % 2 c + r e s p e c t i v e l y % 2 c + d e s p i t e + b o t h % 0 a r e c e i v i n g + a n + a v e r a g e + d a i l y + r e g i m e n + o f + f i v e + a n t i h y p e r t e n s i v e % 0 a m e d i c a t i o n s + t h e + a n a l y s i s + i n c l u d e d + d a t a + f r o m + 4 7 + p a t i e n t s + i n i t i a l l y % 0 a t r e a t e d % 2 c + w h o + a t + 1 2 + m o n t h + f o l l o w - 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