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p a r t y + p a y e r s + w i l l + n o t + o r + n o t + c o n t i n u e + t o + r e i m b u r s e + f o r + t h e + u s e + o f + s o l i r i s + a t + a c c e p t a b l e + r a t e s + o r + a t + a l l % 2 c + a n d + a + v a r i e t y + o f + o t h e r + r i s k s + s e t + f o r t h + f r o m + t i m e - t o - t i m e + i n + o u r + f i l i n g s + w i t h + t h e + s e c % 2 c + i n c l u d i n g + o u r + 1 0 - q + f o r + t h e + q u a r t e r + e n d e d + d e c e m b e r + 3 1 % 2 c + 2 0 1 1 + w e + d o + n o t + i n t e n d + t o + u p d a t e + a n y + o f + t h e s e + f o r w a r d - l o o k i n g + s t a t e m e n t s + a f t e r + t h i s + c a l l + e x c e p t + w h e n + t h e + d u t y + a r i s e s + u n d e r + l a w % 0 a i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 d + l i k e + t o + r e m i n d + y o u + t h a t + o u r + r e p o r t e d + n o n - g a a p + n u m b e r s + c o n f o r m + t o + u s + g a a p + e x c e p t + i n + t h r e e + r e s p e c t s + f i r s t % 2 c + o u r + n o n - g a a p + n u m b e r s + e x c l u d e + s h a r e - b a s e d + c o m p e n s a t i o n + s e c o n d % 2 c + w e + e x c l u d e + n o n - c a s h + t a x + a d j u s t m e n t s + a s s o c i a t e d + w i t h + t h e + u t i l i z a t i o n + o f + o u r + u s + n e t + o p e r a t i n g + l o s s e s + a n d + t h i r d % 2 c + w i t h + c o m p l e t i o n + o f + t h r e e + r e c e n t + a c q u i s i t i o n s % 2 c + w e + a l s o + e x c l u d e + a m o r t i z a t i o n + o f + a c q u i r e d + i n t a n g i b l e + a s s e t s + a n d + c o s t s + a s s o c i a t e d + w i t h + a c q u i s i t i o n s + a + r e c o n c i l i a t i o n + o f + o u r + g a a p + t o + n o n - g a a p + r e s u l t s + i s + i n c l u d e d + i n + t h e + p r e s s + r e l e a s e + w e + i s s u e d + t h i s + m o r n i n g % 0 a t h a n k s + y o u + l e n n y % 3 f % 0 a l e o n a r d + b e l l % 0 a t h a n k s % 2 c + t o m + i n + t h e + f i r s t + q u a r t e r + o f + 2 0 1 2 % 2 c + a l e x i o n + m a d e + s t e a d y + p r o g r e s s + a c r o s s + o u r + s t r a t e g i c + o b j e c t i v e s + f o r + t h e + y e a r + a s + w e + c o n t i n u e + t o + e x p a n d + o u r + i n i t i a t i v e s + t o + d e v e l o p + a n d + d e l i v e r + l i f e + t r a n s f o r m i n g + t h e r a p i e s + f o r + p a t i e n t s + w i t h + s e v e r e + a n d + u l t r a - r a r e + d i s o r d e r s % 0 a o u r + d e v e l o p m e n t + a n d + c o m m e r c i a l + t e a m s + p e r f o r m e d + s o l i d l y + i n + t h r e e + k e y + a r e a s + d u r i n g + t h e + q u a r t e r + f i r s t % 2 c + w e + a g a i n + p r o v i d e d + s o l i r i s + t o + a + s u b s t a n t i a l + n u m b e r + o f + n e w + p a t i e n t s + w i t h + p n h + g l o b a l l y + s e c o n d % 2 c + w e + a r e + v e r y + p l e a s e d + b y + t h e + s t e a d y + i n c r e a s e + i n + n e w + p a t i e n t s + w i t h + a h u s + b e g i n n i n g + t r e a t m e n t + w i t h + s o l i r i s + a n d + f i n a l l y % 2 c + w e + s i g n i f i c a n t l y + a d v a n c e d + o u r + e i g h t + l e a d + d e v e l o p m e n t + p r o g r a m s + w i t h + e c u l i z u m a b + a n d + f o u r + o t h e r + h i g h l y + i n n o v a t i v e + t h e r a p e u t i c s + s t e v e + w i l l + d i s c u s s + t h e + d e t a i l s + a n d + t h e + s p e c i f i c + a r e a s + o f + p r o g r e s s % 2 c + a n d + w h a t + i s + n o w + t h e + b r o a d e s t + p i p e l i n e + i n + a l e x i o n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + h i s t o r y % 0 a i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 d + l i k e + t o + t u r n + f i r s t + o u r + g l o b a l + o p e r a t i o n s + o f + p n h + a n d + a h u s + i n + p n h % 2 c + d u r i n g + q 1 % 2 c + w e + a g a i n + a c h i e v e d + s t e a d y + q u a r t e r - o n - q u a r t e r + g r o w t h + i n + o u r + c o r e + t e r r i t o r i e s + o f + u n i t e d + s t a t e s % 2 c + w e s t e r n + e u r o p e + a n d + j a p a n % 0 a i m p o r t a n t l y + a n d + a s + i n + p r e v i o u s + q u a r t e r s % 2 c + w e + a g a i n + o b s e r v e d + t h a t + a + m a j o r i t y + o f + p n h + p a t i e n t s + n e w l y + s t a r t i n g + o n + s o l i r i s + w e r e + n e w l y + d i a g n o s e d + w i t h + p n h + i n d i c a t i n g + a n + o n g o i n g + a n d + c u m u l a t i v e + i m p a c t + f r o m + o u r + d i s e a s e + a w a r e n e s s + p r o g r a m s + a n d + d i a g n o s t i c s + i n i t i a t i v e s % 0 a w e + a r e + d r i v e n + b y + t h e + r e c o g n i t i o n + t h a t + e v e n + i n + t h e + t e r r i t o r i e s + w h e r e + w e + h a v e + o p e r a t e d + t h e + l o n g e s t % 2 c + t h e + m a j o r i t y + o f + p n h + p a t i e n t s + w h o + c a n + b e n e f i t + f r o m + s o l i r i s + h a v e + s t i l l + n o t + r e c e i v e d + a n + a c c u r a t e + d i a g n o s i s + n o r + s t a r t e d + o n + a p p r o p r i a t e + t h e r a p y % 0 a t u r n i n g + t o + a h u s % 2 c + w e + a r e + v e r y + p l e a s e d + t o + b e + s e r v i n g + a + s t e a d y + e d i t i o n + o f + n e w + p a t i e n t s + b e g i n n i n g + t r e a t m e n t + w i t h + s o l i r i s + i n + q 1 + p a t i e n t s + n e w l y + c o m m e n c i n g + s o l i r i s + t r e a t m e n t + r e p r e s e n t + a + b r o a d + r a n g e + o f + a g e s + a n d + c l i n i c a l + p r o f i l e s % 2 c + a n d + a r e + b e i n g + t r e a t e d + b y + a d u l t + a n d + p e d i a t r i c + n e p h r o l o g i s t s % 2 c + a s + w e l l + a s + h e m a t o l o g i s t s % 2 c + i n d i c a t i n g + b r o a d e r + i n t e r e s t + b y + t h e + f u l l + r a n g e + o f + p h y s i c i a n + w h o + a r e + l i k e l y + t o + t r e a t + p a t i e n t s + w i t h + a h u s % 0 a a s + w e + h a v e + p r e v i o u s l y + n o t e d % 2 c + m o r e + t h a n + h a l f + o f + a h u s + p a t i e n t s + n o t + t r e a t e d + w i t h + s o l i r i s + a r e + k n o w n + t o + a d v a n c e + t o + d i a l y s i s + f r o m + t h e + k i d n e y + d a m a g e + o r + d i e + w i t h i n + t h e + f i r s t + y e a r + o f + f o l l o w i n g + d i a g n o s i s + b a s e d + o n + t h i s + n a t u r a l + h i s t o r y % 2 c + w e + i d e n t i f i e d + t w o + g r o u p s + o f + a h u s + p a t i e n t s + p r i o r + t o + l a u n c h % 0 a p a t i e n t s + w i t h + t h e + l o n g e r + d u r a t i o n + o f + d i s e a s e + a n d + s u b s t a n t i a l + c h r o n i c + k i d n e y + d a m a g e + a n d + a s + e x p e c t e d + a + l a r g e r + p r o p o r t i o n + o f + p a t i e n t s + w e r e + b e i n g + i d e n t i f i e d + d u r i n g + t h e i r + f i r s t + t m a + c l i n i c a l + p r e s e n t a t i o n + a n d + r e q u i r e + e m e r g e n t + m e d i c a l + i n t e r v e n t i o n % 0 a b e f o r e + a p p r o v a l % 2 c + w e + f o c u s e d + o n + b e i n g + a b l e + t o + s e r v e + a l l + t h e + p a t i e n t s + w i t h + a h u s % 2 c + i n c l u d i n g + m e e t i n g + t h e + u r g e n t + n e e d s + o f + n e w l y + p r e s e n t i n g + p a t i e n t s + b y + d e v e l o p i n g + a + r a n g e + o f + p a t i e n t + c e n t e r e d + i n i t i a t i v e s + w e + a r e + v e r y + p l e a s e d + t o + s e e + t h e + e a r l y + p o s i t i v e + i m p a c t + t h a t + o u r + i n i t i a t i v e s + a r e + h a v i n g + o n + t h e + c a r e + o f + p a t i e n t s + w i t h + a h u s % 0 a a s + w e + h a v e + d i s c u s s e d % 2 c + o u r + p n h + a n d + a h u s + o p e r a t i o n s + i n + u n i t e d + s t a t e s + a r e + d r i v e n + b y + o u r + r e c e n t l y + e x p a n d e d + s a l e s + f o r c e % 2 c + w h i c h + i s + s u p p o r t e d + b y + o u r + i n t e g r a t e d + h e m a t o l o g y + a n d + n e p h r o l o g y + t h e r a p e u t i c + a r e a + t e a m s + w e + o b s e r v e d + s t r o n g + m a r k e t i n g + s y n e r g i e s + t h a t + a r e + f o c u s e d + o n + b o t h + h e m a t o l o g y + a n d + n e p h r o l o g y + w i t h + l e a r n i n g + i n + e a c h + a r e a + t h a t + s u p p o r t s + t h e + o t h e r % 0 a o u r + c u r r e n t + c o m m e r c i a l + o p e r a t i o n s + a r e + o n l y + o n e + p a r t + o f + o u r + s t r a t e g y + f o r + m a x i m i z i n g + t h e + t h e r a p e u t i c + v a l u e + o f + s o l i r i s + a s + a + l o n g + s o r t + m e d i c a l + b r e a k t h r o u g h % 2 c + s o l i r i s + h a s + t h e + p o t e n t i a l + t o + t r a n s f o r m + t h e + l i v e s + o f + p a t i e n t s + s u f f e r i n g + f r o m + a + r a n g e + o f + s e v e r e + a n d + u l t r a - r a r e + d i s o r d e r s + o r + u n c o n t r o l l e d + c o m p l e m e n t + a c t i v a t i o n + b e y o n d + p n h + a n d + a h u s % 0 a w e + a r e + c u r r e n t l y + f o c u s e d + o n + a p p l y i n g + t h e + b r e a k t h r o u g h + i n n o v a t i o n + o f + s o l i r i s + a n d + c l i n i c a l + d e v e l o p m e n t + p r o g r a m s + i n + f o u r + s u c h + d i s o r d e r s % 2 c + a c u t e + h u m o r a l + t r a n s p l a n t + r e j e c t i o n % 2 c + s t e c - h u s % 2 c + n e u r o m y e l i t i s + o p t i c a + a n d + m y a s t h e n i a + g r a v i s % 0 a a s + w e + s e e k + t o + m a x i m i z e + t h e + p o t e n t i a l + f o r + s o l i r i s + t o + t r a n s f o r m + t h e + l i v e s + o f + p a t i e n t s % 2 c + w e + a r e + a l s o + w o r k i n g + d i l i g e n t l y + o n + e x p a n d i n g + a n d + a c c e l e r a t i n g + d e v e l o p m e n t + o f + o u r + p o r t f o l i o + o f + o t h e r + h i g h l y + i n n o v a t i v e + t r e a t m e n t s + f o r + p a t i e n t s + w i t h + s e v e r e + a n d + u l t r a - r a r e + d i s o r d e r s % 0 a o u r + l e a d + c l i n i c a l + d e v e l o p m e n t + p r o g r a m s + n o w + c o m p r i s e + f i v e + i n n o v a t i v e + b i o l o g i c s % 2 c + i n c l u d i n g + s o l i r i s % 2 c + c u r r e n t l y + b e i n g + i n v e s t i g a t i n g + i n + e i g h t + s e v e r e + a n d + u l t r a - r a r e + d i s o r d e r s + i n + m u l t i p l e + t h e r a p e u t i c + a r e a s % 0 a i m p o r t a n t l y % 2 c + e v e n + a s + w e + h a v e + s i g n i f i c a n t l y + e x p a n d e d + o u r + d e v e l o p m e n t + p i p e l i n e % 2 c + w e + h a v e + r e c o g n i z e d + a + n e e d + t o + m a i n t a i n + t h e + h i g h e s t + l e v e l + o f + f o c u s + o u r + e i g h t + l e a d + c l i n i c a l + p r o g r a m s + h a v e + b e e n + c h o s e n + f o r + t h e i r + s t r o n g + f i t + w i t h + o u r + l o n g s t a n d i n g + o b j e c t i v e + t o + p u r s u e + t h e + h i g h e s t + l e v e l + o f + m e d i c a l + i n n o v a t i o n + t o + s e r v e + p a t i e n t s % 0 a s p e c i f i c a l l y % 2 c + a l l + o f + t h e s e + d i s o r d e r s + m a n i f e s t + c l i n i c a l + c o m p l i c a t i o n s + t h a t + r a n g e + f r o m + s e r v e + t o + f a t a l + a n d + a l l + a r e + u l t r a - r a r e + i n + t h e + a l i g n m e n t + w i t h + t h e + s e v e r i t y + o f + t h e s e + d i s o r d e r s + a l l + o f + t h e + t h e r a p i e s + w e + h a v e + c h o s e n + t o + d e v e l o p + a r e + h i g h l y + i n n o v a t i v e % 2 c + f i r s t - i n - c l a s s + t r e a t m e n t s + w i t h + s t r o n g + p o t e n t i a l + t o + p r o v i d e + a + l i f e + t r a n s f o r m i n g + i m p a c t + t o + p a t i e n t % 0 a a s + a + r e c e n t + i n d i c a t i o n + o f + o u r + h i g h + s t a n d a r d s + o f + b r e a k t h r o u g h + i n n o v a t i o n % 2 c + w e + n o t e + t h e + p u b l i c a t i o n + l a s t + m o n t h + o f + t h e + h i g h l y + e n c o u r a g i n g + a s f o t a s e + a l f a + p e d i a t r i c + d a t a + i n + t h e + n e w + e n g l a n d + j o u r n a l + o f + m e d i c i n e + g i v e n + t h e i r + v a r i o u s + s t a g e s + o f + d e v e l o p m e n t % 2 c + o u r + l e a d + p i p e l i n e + p r o g r a m s + h a v e + t h e + p o t e n t i a l + t o + m a k e + a + g r o w i n g + c o n t r i b u t i o n + t h r o u g h o u t + o u r + o r g a n i z a t i o n + w e l l + i n t o + t h e + n e x t + d e c a d e % 0 a t u r n i n g + t o + o u r + f i n a n c i a l + p e r f o r m a n c e % 2 c + r e v e n u e s + i n + q 1 + w e r e + % 2 4 2 4 4 7 + m i l l i o n % 2 c + a n + i n c r e a s e + o f + 4 7 % 2 5 + c o m p a r e d + t o + q 1 + 2 0 1 1 + b y + s e r v i n g + a n + i n c r e a s i n g + n u m b e r + o f + p a t i e n t s + w h i l e + m a i n t a i n + r i g o r o u s + f i n a n c i a l + c o n t r o l s % 2 c + w e + a c h i e v e d + q 1 + 2 0 1 2 + n o n - g a a p + n e t + i n c o m e + o f + % 2 4 0 4 5 + p e r + s h a r e + o r + % 2 4 8 8 1 + m i l l i o n % 2 c + 5 7 % 2 5 + i n c r e a s e + y e a r - o v e r - y e a r % 0 a f o l l o w i n g + o u r + p e r f o r m a n c e + i n + q 1 % 2 c + w e + a n n o u n c e d + t h i s + m o r n i n g + t h a t + w e + a r e + r a i s i n g + o u r + 2 0 1 2 + r e v e n u e + g u i d a n c e + f r o m + t h e + p r e v i o u s + r a n g e + o f + % 2 4 1 0 4 + b i l l i o n + t o + % 2 4 1 0 7 + m i l l i o n + n o w + t o + t h e + h i g h e r + a n d + n a r r o w e r + r a n g e + o f + % 2 4 1 0 6 5 + b i l l i o n + t o + % 2 4 1 0 8 5 + b i l l i o n % 0 a a s + w e + i n c r e a s e + o u r + r e v e n u e + f o r e c a s t + f o r + t h e + y e a r + a n d + c o n t i n u e + t o + m a i n t a i n + t i g h t + c o n t r o l + o v e r + e x p e n s e s % 2 c + w e + a l s o + r a i s e d + o u r + g u i d a n c e + f o r + 2 0 1 2 + n o n - g a a p + e p s + f r o m + t h e + p r e v i o u s + r a n g e + o f + % 2 4 1 6 0 + t o + % 2 4 1 7 0 + n o w + t o + t h e + h i g h e r + r a n g e + o f + % 2 4 1 6 5 + t o + % 2 4 1 7 5 % 0 a w e + a r e + g r a t i f i e d + b y + o u r + s t r o n g + s t a r t + i n + 2 0 1 2 + i n c l u d i n g + o u r + v e r y + e n c o u r a g i n g + a n d + s t e a d y + p r o g r e s s + i n + s e r v i n g + p a t i e n t s + w i t h + a h u s % 2 c + a s + w e l l + a s + w i t h + a + s u b s t a n t i a l + e x p a n s i o n + a n d + a c c e l e r a t i o n + o f + o u r + r e s e a r c h + p r o g r a m s % 0 a a s + t h e + y e a r + p r o g r e s s e s + t h e + g l o b a l + a l e x i o n + t e a m + w i l l + d r i v e + f o r w a r d + i n + e a c h + o f + i t s + o p p o r t u n i t i e s + t o + s e r v e + c u r r e n t + a n d + f u t u r e + p a t i e n t s + t o + t h e + w i d e s t + c o m m e r c i a l + o p e r a t i o n s + a n d + t h e + d e e p e s t + d e v e l o p m e n t + p i p e l i n e + i n + o u r + h i s t o r y % 0 a a t + t h i s + p o i n t % 2 c + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + t u r n + t h e + c a l l + o v e r + t o + v i k a s + f o r + a + m o r e + d e t a i l e d + l o o k + a t + o u r + f i n a n c i a l + r e s u l t s + v i k a s % 3 f % 0 a v i k a s + s i n h a % 0 a t h a n k s % 2 c + l e n n y + q 1 + 2 0 1 2 + w a s + a + p e r i o d + o f + s t r o n g + f i n a n c i a l + p e r f o r m a n c e + b y + a l e x i o n + w i t h + s t e a d y + s a l e s + g r o w t h + a n d + i n c r e a s i n g + p r o f i t a b i l i t y + c a s h + f l o w + w a s + a g a i n + r o b u s t + a n d + e x p e n s e s + w e r e + c o n t r o l l e d + w e l l + w i t h i n + o u r + p r e v i o u s l y + s t a t e d + t a r g e t % 0 a n e t + p r o d u c t + s a l e s + o f + s o l i r i s + w e r e + % 2 4 2 4 4 7 + m i l l i o n + i n + q 1 % 2 c + a n + i n c r e a s e + o f + 4 7 % 2 5 + c o m p a r e d + t o + t h e + y e a r + a g o + q u a r t e r + r e v e n u e + p e r f o r m a n c e + i n + q 1 + w a s + s u p p o r t e d + b y + o u r + c o r e + g e o g r a p h i e s + o f + t h e + u s % 2 c + w e s t e r n + e u r o p e + a n d + j a p a n % 2 c + a u g m e n t e d + b y + s e r v i n g + a + s m a l l + b u t + g r o w i n g + n u m b e r + o f + p a t i e n t s + i n + o t h e r + c o u n t r i e s % 0 a a s + w e + e x e c u t e d + s t r o n g l y + o n + p a t i e n t + c e n t e r e d + i n i t i a t i v e s + i n + q 1 % 2 c + w e + c o n t i n u e d + t o + c o n t r o l + b o t h + s g % 2 6 a + a n d + r % 2 6 d + e x p e n s e s + i n + q 1 % 2 c + n o n - g a a p + s g % 2 6 a + w a s + % 2 4 7 7 9 + m i l l i o n + a n d + n o n - g a a p + r % 2 6 d + w a s + % 2 4 4 2 1 + m i l l i o n % 0 a s t r o n g + t o p l i n e + p e r f o r m a n c e + c o m b i n e d + w i t h + c o n t r o l + o f + o t h e r + k e y + f i n a n c i a l + p a r a m e t e r s + r e s u l t e d + i n + a + 5 7 % 2 5 + i n c r e a s e + i n + o u r + n o n - g a a p + n e t + i n c o m e + y e a r - o v e r - y e a r + t o + % 2 4 8 8 1 + m i l l i o n + o r + % 2 4 0 4 5 + p e r + s h a r e + i n + q 1 + 2 0 1 2 % 0 a t u r n i n g + t o + o u r + b a l a n c e + s h e e t % 2 c + c a s h % 2 c + c a s h + e q u i v a l e n c e + a n d + m a r k e t a b l e + s e c u r i t i e s + a t + q u a r t e r + e n d + w e r e + % 2 4 3 5 9 + m i l l i o n + t h e s e + r e f l e c t + p o s i t i v e + c a s h + f l o w + f r o m + o p e r a t i o n s + d u r i n g + t h e + q u a r t e r + a n d + a c q u i s i t i o n + r e l a t e d + d e b t + o f f s e t + b y + p a y m e n t + f o r + t h e + p u r c h a s e + o f + e n o b i a % 0 a i + w o u l d + n o w + l i k e + t o + r e v i e w + o u r + g u i d a n c e + f o l l o w i n g + o u r + p e r f o r m a n c e + i n + q 1 % 2 c + w e + a n n o u n c e d + t h i s + m o r n i n g + t h a t + w e + a r e + r a i s i n g + o u r + 2 0 1 2 + r e v e n u e + g u i d a n c e + f r o m + t h e + p r e v i o u s + r a n g e + o f + % 2 4 1 0 4 + b i l l i o n + t o + % 2 4 1 0 7 + b i l l i o n + n o w + t o + t h e + h i g h e r + a n d + n a r r o w e r + r a n g e + o f + % 2 4 1 0 6 5 + b i l l i o n + t o + % 2 4 1 0 8 5 + b i l l i o n % 0 a a s + w e + i n c r e a s e + o u r + r e v e n u e + f o r e c a s t + f o r + t h e + y e a r + a n d + c o n t i n u e + t o + m a i n t a i n + t i g h t + c o n t r o l + o v e r + e x p e n s e s % 2 c + w e + h a v e + a l s o + r a i s e d + o u r + g u i d a n c e + f o r + 2 0 1 2 + n o n - g a a p + e p s + f r o m + t h e + p r e v i o u s + r a n g e + o f + % 2 4 1 6 0 + t o + % 2 4 1 7 0 + n o w + t o + t h e + h i g h e r + r a n g e + o f + % 2 4 1 6 5 + t o + % 2 4 1 7 5 % 0 a w h i l e % 2 c + a l l + o t h e r + i t e m s + o f + t h e + g u i d a n c e + a r e + b e i n g + r e i t e r a t e d % 2 c + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 d + l i k e + t o + p r o v i d e + s o m e + i n s i g h t s + i n t o + o u r + r e m a i n i n g + n o n - g a a p + s g % 2 6 a + a n d + r % 2 6 d + e x p e n s e s % 2 c + a n d + o u r + g a a p + t a x + r a t e % 0 a f i r s t % 2 c + i + w o u l d + n o t e + t h a t + n o n - g a a p + s g % 2 6 a + i s + h i s t o r i c a l l y + l o w e r + i n + q 1 % 2 c + c o m p a r e d + t o + o t h e r + q u a r t e r s + i n + p a r t i c u l a r % 2 c + w e + e x p e c t + t o + h a v e + s i g n i f i c a n t l y + g r e a t e r + n o n - g a a p + s g % 2 6 a + e x p e n s e s + i n + q 2 + a n d + q 4 + d u e + t o + e x p e n s e s + r e l a t e d + t o + m e d i c a l + c o n f e r e n c e s % 0 a a d d i t i o n a l l y % 2 c + e x c l u d e d + f r o m + o u r + n o n - g a a p + s g % 2 6 a + i n + 2 0 1 2 + w i l l + b e + a p p r o x i m a t e l y + % 2 4 2 0 + m i l l i o n + t o + % 2 4 2 5 + m i l l i o n + i n + a c q u i s i t i o n - r e l a t e d + c o s t + f o r + e n o b i a + a n d + w e + h a v e + a l r e a d y + r e c o g n i z e d + % 2 4 1 2 4 + m i l l i o n + o f + t h i s + c o s t + i n + q 1 % 0 a t u r n i n g + t o + n o n - g a a p + r % 2 6 d % 2 c + w e + e x p e c t + t h a t + n o n - g a a p + r % 2 6 d + i n + q 2 + w i l l + i n c r e a s e + t o + a p p r o x i m a t e l y + % 2 4 6 3 + m i l l i o n + t o + % 2 4 6 8 + m i l l i o n % 2 c + m a i n l y + d r i v e n + b y + a s f o t a s e + a l f a + m a n u f a c t u r i n g + a n d + d e v e l o p m e n t + c o s t s % 0 a f a l l i n g + t h i s + p e a k + i n + q 2 % 2 c + w e + e x p e c t + r % 2 6 d + t o + b e + l o w e r + i n + q 3 + t h a n + i n + q 2 % 2 c + t h o u g h + s t i l l + a b o v e + t h e + q 1 + l e v e l + w e + c o n t i n u e + t o + e x p e c t + t h a t + a s + a + r e s u l t + o f + e x t r a + e x p e n s e s + r e l a t e d + t o + e n o b i a % 2 c + r % 2 6 d + w i l l + b e + 2 1 % 2 5 + o f + s a l e s + i n + 2 0 1 2 + a n d + w i l l + r e t u r n + t o + o u r + t a r g e t + l e v e l s + o f + 1 7 % 2 5 + t o + 1 8 % 2 5 + o f + s a l e s + i n + 2 0 1 3 % 0 a f i n a l l y % 2 c + r e g a r d i n g + t a x e s % 2 c + w e + e x p e c t + t o + i n c u r + a + % 2 4 2 0 + m i l l i o n + t o + % 2 4 3 0 + m i l l i o n + t a x + e x p e n s e + i n + q 2 + f o r + t h e + i n t e g r a t i o n + a n d + s t r u c t u r i n g + o f + t h e + e n o b i a + a c q u i s i t i o n + e x c l u d i n g + t h i s + c h a r g e % 2 c + w e + c o n t i n u e + t o + e x p e c t + o u r + 2 0 1 2 + g a a p + t a x + r a t e + o f + 3 2 % 2 5 + t o + 3 4 % 2 5 + o u r + n o n - g a a p + t a x + r a t e + f o r e c a s t + o f + 8 % 2 5 + t o + 1 0 % 2 5 + r e m a i n s + u n c h a n g e d % 0 a i m p o r t a n t l y % 2 c + w e + e x p e c t + t o + r e a l i z e + s u b s t a n t i a l + l o n g - t e r m + f i n a n c i a l + b e n e f i t s + f r o m + t h e + s t r u c t u r i n g + o f + o u r + o r g a n i z a t i o n + a s + w e + i n t e g r a t e + e n o b i a % 0 a o v e r a l l % 2 c + w e + a r e + v e r y + p l e a s e d + w i t h + o u r + p e r f o r m a n c e + i n + t h e + f i r s t + q u a r t e r + o f + 2 0 1 2 + w e + a r e + e s p e c i a l l y + g r a t i f i e d + a t + t h e + d i s c i p l i n e + w i t h + w h i c h + w e + a r e + e x p e c t i n g + o u r + c o m m e r c i a l + p l a t f o r m + i n + o u r + d e v e l o p m e n t + p r o g r a m s + a n d + t h e + e f f i c i e n c y + w i t h + w h i c h + w e + a r e + i n t e g r a t i n g + o u r + a c q u i r e d + d r u g + c a n d i d a t e s + i n t o + a + p i p e l i n e + w i t h i n + o u r + f i n a n c i a l + p a r a m e t e r % 0 a a t + t h i s + p o i n t % 2 c + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + t u r n + t h e + c a l l + o v e r + t o + d a v i d + w h o + w i l l + p r o v i d e + a n + u p d a t e + o f + o u r + g l o b a l + c o m m e r c i a l + o p e r a t i o n s + d a v i d % 3 f % 0 a d a v i d + h a l l a l % 0 a t h a n k s % 2 c + v i k a s + i n + t h e + f i r s t + q u a r t e r + o f + 2 0 1 2 % 2 c + g l o b a l + r e v e n u e s + f r o m + o u r + s o l i r i s + o p e r a t i o n s + i n c r e a s e d + b y + 4 7 % 2 5 + c o m p a r e d + t o + t h e + f i r s t + q u a r t e r + o f + 2 0 1 1 + q 1 + r e v e n u e s + r e f l e c t + s t e a d y + a d d i t i o n s + o f + n e w + p n h + p a t i e n t s + i n + o u r + c o r e + t e r r i t o r i e s + o f + t h e + u s % 2 c + w e s t e r n + e u r o p e + a n d + j a p a n + a u g m e n t e d + b y + a + s t e a d y + i n c r e a s e + i n + n e w + p a t i e n t s + w i t h + a h u s + c o m m e n c i n g + t r e a t m e n t + w i t h + s o l i r i s % 0 a l o o k i n g + m o r e + c l o s e l y + a t + p n h % 2 c + w e + a r e + g r a t i f i e d + t o + o b s e r v e + t h e + t r e a t m e n t + i s + i n c r e a s i n g l y + b e i n g + o p t i m i z e d + f o r + p a t i e n t s + t h r o u g h + o u r + d i s e a s e + a w a r e n e s s + p r o g r a m s % 2 c + w e + a r e + d i s c u s s i n g + w i t h + p h y s i c i a n s + t h e + l a r g e + a n d + g r o w i n g + b o d y + o f + c l i n i c a l + e v i d e n c e + r e g a r d i n g + t h e + m o r b i d i t i e s + a n d + p r e m a t u r e + m o r t a l i t y + a s s o c i a t e d + w i t h + p n h + a n d + t h e + p o s i t i v e + l o n g - t e r m + o u t c o m e s + d e m o n s t r a t e d + w i t h + s o l i r i s + t r e a t m e n t % 0 a s i m i l a r l y % 2 c + o u r + d i a g n o s t i c + i n i t i a t i v e s + a r e + a i d e d + b y + p u b l i c a t i o n s % 2 c + w h i c h + r e c o m m e n d + t e s t i n g + f o r + p a t i e n t s + a t + h i g h e r + l i k e l i h o o d + f o r + h a v i n g + t h e + d i s e a s e + g i v e n + t h e + c l i n i c a l + e v i d e n c e % 2 c + m o r e + p a t i e n t s + a r e + b e i n g + t e s t e d + a n d + i f + t h e y + a r e + d e t e r m i n e d + t o + h a v e + p n h % 2 c + t h e i r + p h y s i c i a n s + a r e + m o r e + l i k e l y + t o + r a p i d l y + i n i t i a t e + t r e a t m e n t + w i t h + s o l i r i s % 0 a o u r + v i e w + o f + t h e + g l o b a l + l a n d s c a p e + r e m a i n s + u n c h a n g e d + w e + c o n t i n u e + t o + f i n d + t h a t + t h e + m a j o r i t y + o f + p a t i e n t s + w i t h + p n h + h a v e + n o t + y e t + r e c e i v e d + a n + a c c u r a t e + d i a g n o s i s + l e t + a l o n e + a r e + r e c e i v i n g + a p p r o p r i a t e + t r e a t m e n t % 2 c + e v e n + i n + t h o s e + c o u n t r i e s + w h e r e + w e + h a v e + b e e n + o p e r a t i n g + t h e + l o n g e s t % 0 a a s + w e + e x p a n d + o u r + d i s e a s e + e d u c a t i o n + a n d + d i a g n o s t i c + e f f o r t s + i n + b o t h + e x i s t i n g + a n d + n e w + c o u n t r i e s % 2 c + w e + b e l i e v e + w e + w i l l + c o n t i n u e + t o + t r a n s f o r m + t h e + l i v e s + o f + m o r e + p a t i e n t s + w i t h + p n h + a r o u n d + t h e + w o r l d % 0 a t u r n i n g + t o + a h u s % 2 c + w e + a r e + v e r y + p l e a s e d + w i t h + t h e + s e c o n d + f u l l + q u a r t e r + o f + o u r + a h u s + l a u n c h + w i t h + a + s t e a d y + a d d i t i o n + o f + n e w + p a t i e n t s + b e g i n n i n g + t r e a t m e n t + w i t h + s o l i r i s + i n + q 1 + i m p o r t a n t l y % 2 c + w e + n o t e + s e v e r a l + d y n a m i c s + f r o m + t h e + e a r l y + s t a g e s + o f + o u r + a h u s + l a u n c h % 0 a f i r s t % 2 c + w e + a r e + o b s e r v i n g + t h a t + p a t i e n t s + w h o + a r e + r e c e i v i n g + s o l i r i s + r e p r e s e n t + a + b r o a d + r a n g e + o f + a g e s + a n d + c l i n i c a l + p r o f i l e s % 2 c + i n c l u d i n g + t h o s e + w i t h + l o n g - t e r m + d i s e a s e + a n d + c h r o n i c + k i d n e y + d a m a g e + a s + w e l l + a s + t h o s e + w h o + a r e + b e i n g + i d e n t i f i e d + d u r i n g + t h e i r + f i r s t + t m a + c l i n i c a l + p r e s e n t a t i o n % 0 a s e c o n d % 2 c + w e + c o n t i n u e d + t o + o b s e r v e + t h a t + a + s i g n i f i c a n t + p r o p o r t i o n + o f + t h e + n e w + p r e s c r i b e r s + o f + s o l i r i s + f o r + p a t i e n t s + w i t h + a h u s + a r e + h e m a t o l o g i s t s + t h u s % 2 c + w e + a r e + a b l e + t o + a p p l y + o u r + l o n g - t e r m + p r e s e n c e + i n + h e m a t o l o g y + f o r + t h e + b e n e f i t + f o r + b o t h + p n h + a n d + a h u s + p a t i e n t s % 0 a a n d + t h i r d % 2 c + o u r + d e c i s i o n + t o + e x p a n d + o u r + s a l e s + t e a m + i n + t h e + u n i t e d + s t a t e s + h a s + e n a b l e d + u s + t o + g r o w + o u r + p r e s e n t + a n d + i n c r e a s e + r e a c h + a n d + f r e q u e n c y + o f + o u r + i n t e r a c t i o n + a m o n g s t + b o t h + h e m a t o l o g i s t + a n d + n e p h r o l o g i s t s % 2 c + a s + e a c h + r e p r e s e n t a t i v e + i s + a b l e + t o + f o c u s + o n + m o r e + p h y s i c i a n s + i n + a + s m a l l e r + g e o g r a p h i c + a r e a % 0 a i m p o r t a n t l y % 2 c + o u r + a h u s + d i s e a s e + a w a r e n e s s + p r o g r a m s % 2 c + w h i c h + a r e + f o c u s e d + o n + t h e + m o r b i d i t i e s + a n d + m o r t a l i t y + o f + a h u s + a r e + u n d e r w a y + a n d + a r e + b e i n g + w e l l + r e c e i v e d + b y + p h y s i c i a n s + t h e s e + p r o g r a m s + h e l p + e d u c a t e + p h y s i c i a n s + o n + t h e + e a r l y + s i g n s + a n d + s y m p t o m s + o f + a h u s % 2 c + t h e + r o l e + o f + c h r o n i c + u n c o n t r o l l e d + c o m p l i m e n t + a c t i v a t i o n + a s + t h e + u n d e r l y i n g + c a u s e + o f + t m a + i n + t h e s e + p a t i e n t s + a n d + t h e + c o m p e l l i n g + c l i n i c a l + b e n e f i t s + t h a t + s o l i r i s + c a n + p r o v i d e + t o + p a t i e n t + w i t h + a h u s + b y + i n h i b i t i n g + c o m p l i m e n t - m e d i a t e d + t m a % 0 a b a s e d + u p + o n + t h e + n o + n a t u r a l + h i s t o r y + o f + a h u s % 2 c + w e + i d e n t i f i e d + t w o + g r o u p s + o f + p a t i e n t s + w i t h + a h u s + p r i o r + t o + l a u n c h + p a t i e n t s + w i t h + a + l o n g e r + d u r a t i o n + o f + d i s e a s e + a n d + s u b s t a n t i a l + k i d n e y + d a m a g e + a n d + a s + e x p e c t e d + a + l a r g e r + p r o p o r t i o n + o f + p a t i e n t s + w h o + a r e + i d e n t i f i e d + d u r i n g + t h e i r + f i r s t + t m a + c l i n i c a l + p r e s e n t a t i o n + a n d + r e q u i r e + i m m e d i a t e + m e d i c a l + i n t e r v e n t i o n % 0 a b e f o r e + a p p r o v a l % 2 c + w e + f o c u s e d + o n + b e i n g + a b l e + t o + s e r v e + a l l + p a t i e n t s + w i t h + a h u s % 2 c + i n c l u d i n g + m e e t i n g + t h e + u r g e n t + n e e d s + o f + n e w l y + p r e s e n t i n g + p a t i e n t + b y + d e v e l o p i n g + a + b r o a d + r a n g e + o f + p a t i e n t - c e n t e r e d + i n i t i a t i v e s + i n + t h e + a r e a s + o f + d i s e a s e + a w a r e n e s s % 2 c + p a t i e n t + d i a g n o s i s % 2 c + r e i m b u r s e m e n t + s u p p o r t + a n d + p r o v i d i n g + s u p p l y + o f + s o l i r i s + t o + t r e a t m e n t + s i t e s + w i t h i n + h o u r s % 0 a f o r + t h e + i m p l e m e n t a t i o n + o f + t h e s e + i n i t i a t i v e s % 2 c + w e + a r e + c u r r e n t l y + s u p p o r t i n g + a n + i n c r e a s i n g + n u m b e r + o f + p h y s i c i a n s + a s + t h e y + i d e n t i f y + e m e r g i n g + a h u s + p a t i e n t s + a n d + s e e k + t o + s t a r t + t h e m + o n + s o l i r i s + t h e r a p y + w i t h o u t + d e l a y % 0 a w e + a r e + p l e a s e d + w i t h + t h e + e a r l y + p o s i t i v e + i m p a c t + t h a t + t h e s e + i n i t i a t i v e s + a r e + h a v i n g + o n + t h e + p a t i e n t + c a r e + a n d + l o o k + f o r w a r d + t o + s e r v i n g + m o r e + p a t i e n t s + w i t h + a h u s + i n + t h e + u n i t e d + s t a t e s + o v e r t i m e % 0 a t u r n i n g + b r i e f l y + t o + o u r + u p c o m i n g + a h u s + l a u n c h + i n + e u r o p e % 2 c + w e + a r e + o n + t r a c k + w i t h + o u r + r e i m b u r s e m e n t + d i s c u s s i o n s + w i t h + h e a l t h c a r e + a u t h o r i t i e s + i n + m a j o r + e u r o p e a n + c o u n t r i e s + w e + e x p e c t + t o + s t a r t + s e r v i n g + p a t i e n t s + w i t h + a h u s + i n + i n i t i a l + e u r o p e a n + c o u n t r i e s + l a t e r + i n + 2 0 1 2 + w i t h + o t h e r s + c o m m e n c i n g + t h r o u g h + m i d - 2 0 1 3 % 0 a t o + p r e p a r e + f o r + o u r + e u + l a u n c h e s % 2 c + w e + w i l l + s t a r t + t o + e x p a n d + o u r + e u r o p e a n + f i e l d + t e a m s + o n + a + c o u n t r y - b y - c o u n t r y + b a s i s + w i t h + p r o f e s s i o n a l s + w h o + h a v e + e x p e r i e n c e + i n + r a r e + d i s o r d e r s + a n d + r e l e v a n t + m e d i c a l + s p e c i a l t y + a s + i n + t h e + u s % 2 c + e a c h + m e m b e r + o f + o u r + e x p a n d e d + e u r o p e a n + f i e l d + t e a m s + w i l l + b e + f u l l y + c r o s s + t r a i n e d + o n + b o t h + p n h + a n d + a h u s + a n d + w i l l + m a n a g e + a + s m a l l e r + t e r r i t o r y + t h a n + i n + t h e + p a s t % 0 a w h i l e + w e + e x p e c t + t h a t + t h e + i n i t i a l + u s e + o f + s o l i r i s + a n d + a h u s + i n + e u r o p e + w i l l + g r o w + o n l y + g r a d u a l l y + d u e + t o + t h e + l o w + p r e v a l e n c e + a n d + l o w + a w a r e n e s s + o f + t h e + d i s e a s e % 2 c + w e + a r e + c o n f i d e n t + t h a t + w e + w i l l + s e r v e + a n + i n c r e a s i n g + n u m b e r + o f + e u r o p e a n + p a t i e n t s + w i t h + a h u s + o v e r + t i m e % 0 a t u r n i n g + n o w + t o + h p p + i n + m a r c h % 2 c + w e + a t t e n d e d + t h e + a m e r i c a n + c o l l e g e + o f + m e d i c a l + g e n e t i c s + m e e t i n g + w h e r e + w e + p r o v i d e d + d i s e a s e + i n f o r m a t i o n + a n d + m e t + w i t h + p h y s i c i a n s + w h o + h a v e + e x p e r i e n c e d + t r e a t i n g + p a t i e n t s + w i t h + h p p + l i k e + p n h + a n d + a h u s % 2 c + w e + k n o w + t h a t + h p p + i s + o f t e n + m i s u n d e r s t o o d + g i v e n + t h e + r a r i t y + o f + t h e + d i s o r d e r + a n d + t h e + w i d e + r a n g e + o f + i t s + c l i n i c a l + s i g n s % 0 a t h u s % 2 c + w e + b e l i e v e + t h a t + d i s e a s e + a w a r e n e s s + a n d + d i a g n o s t i c + i n i t i a t i v e s + w i l l + b e + a + c r i t i c a l + c o m p o n e n t + o f + o u r + c o m m e r c i a l + p r o g r a m + a s + w e + p r e p a r e + f o r + t h e + p o t e n t i a l + i n t r o d u c t i o n + o f + a s f o t a s e + a l f a + a s + o u r + c l i n i c a l + a n d + r e g u l a t o r y + t e a m s + d r i v e + t h e + d e v e l o p m e n t + p r o g r a m + f o r w a r d % 2 c + t h e + c o m m e r c i a l + t e a m + w i l l + c o n t i n u e + t o + a s s e s s + t h e + n e e d s + o f + t h e + h p p + c o m m u n i t y + a s + w e + p r e p a r e + f o r + t h e + p o t e n t i a l + i n t r o d u c t i o n + o f + a s f o t a s e + a l f a % 0 a l o o k i n g + a h e a d % 2 c + w e + a r e + d r i v i n g + f o r w a r d + o n + e v e r y + f r o n t + t o + t r a n s f o r m + t h e + l i v e s + o f + m o r e + p a t i e n t s + i n + m o r e + c o u n t r i e s + w h o + a r e + s u f f e r i n g + w i t h + p n h + a n d + a h u s + w h i l e + b e g i n n i n g + t o + p r e p a r e + f o r + n e w + s o l i r i s + i n d i c a t i o n s + a n d + t h e + l a u n c h + o f + a s f o t a s e + a l f a + d r i v e n + b y + o u r + c o m m i t m e n t + t o + p a t i e n t s + a n d + f a m i l i e s % 2 c + o u r + g l o b a l + c o m m e r c i a l + o p e r a t i o n s + t e a m + w i l l + c o n t i n u e + t o + e m p l o y + t h e i r + e x p e r i e n c e % 2 c + s k i l l s + a n d + t a l e n t + t o + a c h i e v e + o u r + o b j e c t i v e s + f o r + m a n y + y e a r s + t o + c o m e % 0 a n o w % 2 c + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + t u r n + t h e + c a l l + o v e r + t o + s t e v e % 2 c + w h o % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + r e v i e w + o u r + e x p a n d i n g + p i p e l i n e + i n i t i a t i v e s + s t e v e % 3 f % 0 a s t e v e + s q u i n t o % 0 a t h a n k s % 2 c + d a v i d + i n + t h e + f i r s t + q u a r t e r + o f + 2 0 1 2 % 2 c + w e + c o n t i n u e + t o + m a k e + s u b s t a n t i a l + p r o g r e s s + i n + o u r + l e a d + p i p e l i n e + p r o g r a m s % 2 c + w h i c h + i n c l u d e + f i v e + h i g h l y + i n n o v a t i v e + c o m p o u n d s + c u r r e n t l y + b e i n g + i n v e s t i g a t e d + a t + v a r i o u s + s t a g e s + o f + d e v e l o p m e n t + a c r o s s + e i g h t + s e v e r e + a n d + u l t r a - r a r e + i n d i c a t i o n s + b e y o n d + p n h + a n d + a h u s % 0 a i + w o u l d + f i r s t + l i k e + t o + p r o v i d e + a n + u p d a t e + o n + o u r + e c u l i z u m a b + p r o g r a m s % 2 c + s t a r t i n g + w i t h + s t e c - h u s + o u t + o f + t h e + t o t a l + 1 9 8 + p a t i e n t s + e n r o l l e d + i n + o u r + s t e c - h u s + s t u d y + i n + g e r m a n y % 2 c + t h e + i n t e r i m + d a t a + p r e s e n t e d + i n + n o v e m b e r + w e r e + f r o m + t h e + 1 4 8 + p a t i e n t s + w h o + w e r e + t r e a t e d + a t + t h e + f i r s t + n i n e + c l i n i c a l + t r i a l + s i t e s % 0 a t h e + i n t e r i m + d a t a + w e r e + v e r y + e n c o u r a g i n g + d e m o n s t r a t i n g + t h a t + e c u l i z u m a b + t r e a t m e n t + f o r + e i g h t - w e e k s + s u b s t a n t i a l l y + r e d u c e + t h e + o c c u r r e n c e + o f + s e r i o u s + m o r b i d i t i e s + i n + s t e c - h u s + p a t i e n t s + i n t e r i m + d a t a + s h o w e d + a + r a p i d % 2 c + l a r g e + a n d + s u s t a i n e d + r e d u c t i o n + i n + t h r o m b o t i c + m i c r o a n g i o p a t h y + o r + t m a + a n d + r e v e r s a l + o f + o r g a n + d a m a g e + w i t h + e c u l i z u m a b + t r e a t m e n t % 0 a p a t i e n t s + i n + t h e + s t u d y + w e r e + o b s e r v e d + f o r + 2 8 + w e e k s + f o l l o w i n g + t r e a t m e n t + i n i t i a t i o n + w e + h a v e + n o w + c o m m e n c e d + t h e + n o r m a l + p r o c e s s + o f + d a t a + c o l l e c t i o n + a n d + d a t a + c l e a n i n g + f o r + s u b s e q u e n t + d a t a + b a s e + l o c k + a n d + a n a l y s i s + f o r + t h e + o v e r a l l + 1 9 8 + p a t i e n t + i n t e n s i v e + t r e a t + g r o u p % 0 a a f t e r + t h e + f i n a l + s t e p s + a r e + c o n c l u d e d % 2 c + w e + e x p e c t + t o + h a v e + d i s c u s s i o n s + w i t h + r e g u l a t o r s + r e g a r d i n g + a + p a t h w a y + f o r + f i l i n g + a n + s p l a + a s + e a r l y + a s + t h e + s e c o n d + h a l f + o f + t h i s + y e a r + i n + o u r + k i d n e y + t r a n s p l a n t + p r o g r a m + w i t h + e c u l i z u m a b % 2 c + w e + c o n t i n u e + t o + e n r o l l + p a t i e n t s + i n + o u r + c o m p a n y - s p o n s o r e d + m u l t i n a t i o n a l + l i v i n g + d o n o r + k i d n e y + t r a n s p l a n t + t r i a l + i n + p a t i e n t s + a t + e l e v a t e d + r i s k + o f + a n t i b o d y - m e d i a t e d + r e j e c t i o n % 0 a p a t i e n t s + i n + t h i s + s t u d y + a r e + b e i n g + d o s e d + w i t h + e c u l i z u m a b + f o r + n i n e + w e e k s + p o s t - t r a n s p l a n t + a n d + t h e n + w i l l + b e + o b s e r v e d + f o r + 5 2 + w e e k s + f o l l o w i n g + t r a n s p l a n t + i n + a d d i t i o n % 2 c + w e + e x p e c t + t o + i n i t i a t e + a + d i s e a s e + d o n o r + s t u d y + i n + t h e + s u m m e r + o f + t h i s + y e a r % 0 a w e + a l s o + h a v e + t w o + n e u r o l o g y + c l i n i c a l + d e v e l o p m e n t + p r o g r a m s + o n g o i n g + w i t h + e c u l i z u m a b % 2 c + i n + s e v e r e + a n d + r e f r a c t o r y + n e u r o m y e l i t i s + o p t i c a + a n d + i n + m y a s t h e n i a + g r a v i s + d a t a + f r o m + t h e + i n v e s t i g a t o r + i n i t i a t e d + p h a s e + 2 + c l i n i c a l + t r i a l + o f + e c u l i z u m a b + i n + s e v e r e + r e f r a c t o r y + n m o + i s + e x p e c t e d + t o + b e + p r e s e n t e d + a t + a + s c i e n t i f i c + m e e t i n g + i n + t h e + s e c o n d + h a l f + o f + 2 0 1 2 + e v e n + b e f o r e + t h e s e + d a t a + a r e + p r e s e n t e d % 2 c + w e + e x p e c t + t o + h o l d + a + s e r i e s + o f + d i s c u s s i o n s + w i t h + i n v e s t i g a t o r s + t o + d e s i g n + t h e + n e x t + s t u d y + p r i o r + t o + o u r + a n t i c i p a t e d + m e e t i n g + w i t h + r e g u l a t o r s % 0 a w i t h + r e g a r d + t o + m y a s t h e n i a + g r a v i s % 2 c + a d d i t i o n a l + d a t a + f r o m + t h e + 1 4 + p a t i e n t + p h a s e + 2 + s t u d y + a r e + b e i n g + p r e s e n t e d + a t + t h e + a m e r i c a n + a c a d e m y + o f + n e u r o l o g y + a n n u a l + m e e t i n g + t h i s + m o n t h + w e + e x p e c t + t o + d i s c u s s + t h e + p l a n s + f o r + a + l a r g e r + p e r s p e c t i v e + c o n t r o l l e d + s t u d y + w i t h + r e g u l a t o r s + i n + 2 0 1 2 % 0 a i + w o u l d + l i k e + t o + t u r n + n o w + t o + o u r + o t h e r + l e a d + d e v e l o p m e n t + p r o g r a m + w i t h + h i g h l y + i n n o v a t i v e + t h e r a p e u t i c s + b e y o n d + e c u l i z u m a b % 2 c + s t a r t i n g + w i t h + a s f o t a s e + a l f a + w e + a r e + h i g h l y + e n c o u r a g e d + b y + t h e + p r o g r e s s + m a d e + i n + a s f o t a s e + a l f a + c l i n i c a l + d e v e l o p m e n t + i n + j u s t + t h e + f i r s t + q u a r t e r + o f + t h i s + y e a r + i t + i s + n o t e w o r t h y + t h a t + t h i s + s i g n i f i c a n t + p r o g r e s s + w a s + d e m o n s t r a t e d + i n + t h e + t h r e e + d i s t i n c t + t r i a l s + a c r o s s + a + b r o a d + s p e c t r u m + o f + h p p + p a t i e n t s % 0 a t u r n i n g + f i r s t + t o + p e d i a t r i c + p a t i e n t s + o u r + p h a s e + 2 + s t u d y + o f + i n f a n t s + a n d + y o u n g + c h i l d r e n + w i t h + l i f e - t h r e a t e n i n g + h p p + w e r e + p u b l i s h e d + i n + t h e + n e w + e n g l a n d + j o u r n a l + o f + m e d i c i n e + i n + m a r c h + i m p o r t a n t l y % 2 c + a l l + t h e + p a t i e n t s + t r e a t e d + w i t h + a s f o t a s e + a l f a + d e m o n s t r a t e d + a n + i m p r o v e m e n t + i n + b l o o d + l e v e l s + o f + p p i + a n d + p l p % 2 c + t w o + k e y + b i o c h e m i c a l + i n d i c a t o r s + o f + h p p + p r o v i d i n g + s t r o n g + s u p p o r t + f o r + t h e + p o t e n t i a l + o f + a s f o t a s e + a l f a + t o + c o r r e c t + t h e + u n d e r l y i n g + e n z y m e + d e f i c i e n c y + i n + p a t i e n t s + w i t h + h p p % 0 a t h e + s t u d y + m a d e + i t s + p r i m a r y + e n d + p o i n t + w i t h + 9 0 % 2 5 + o f + p a t i e n t s + s h o w i n g + s u b s t a n t i a l + s k e l e t a l + h e a l i n g + a t + 2 4 - w e e k s + o f + t r e a t m e n t + w i t h + a s f o t a s e + a l f a + i n + t h e + s t u d y % 2 c + s k e l e t a l + h e a l i n g + b e c a m e + a p p a r e n t + a s + e a r l y + a s + w e e k + t h r e e + a l l + p a t i e n t s + t r e a t e d + w i t h + a s f o t a s e + a l f a + a l s o + h a d + a n + i m p r o v e m e n t + i n + r e s p i r a t o r y + f u n c t i o n + a n d + p a t i e n t s + a l s o + d e m o n s t r a t e d + i m p r o v e m e n t s + i n + f i n e + m o t o r + a n d + g r o s s + m o t o r + f u n c t i o n + a n d + c o g n i t i v e + d e v e l o p m e n t + t h e s e + f i n d i n g s + a r e + r e m a r k a b l e + g i v e n + t h e + h i s t o r i c a l l y + g r i m + o u t l o o k + f o r + p a t i e n t s + w i t h + l i f e + t h r e a t e n i n g + h p p % 0 a a l s o + i n + p e d i a t r i c s % 2 c + d a t a + i n + j u v e n i l e s + w e r e + p r e s e n t e d + a t + t h e + s a n f o r d + b u r n h a m + r a r e + d i s e a s e + d a y + s y m p o s i u m + i n + f e b r u a r y + d a t a + s h o w e d + t h a t + a l l + p a t i e n t s + w h o + w e r e + t r e a t e d + w i t h + a s f o t a s e + a l f a + h a d + a n + o b j e c t i v e + r e s p o n s e + t o + t h e r a p y % 2 c + w i t h + c l i n i c a l l y + a n d + s t a t i s t i c a l l y + m e a n i n g f u l + d e c r e a s e s + i n + e n z y m e + s u b s t r a t e + t h e s e + b i o c h e m i c a l + i m p r o v e m e n t s + w e r e + a c c o m p a n i e d + b y + i m p r o v e m e n t + i n + b o n e + m i n e r a l i z a t i o n + a s + e v i d e n c e + b y + b o t h + b o n e + b i o p s y + a n d + r a d i o g r a p h i c + i m p r o v e m e n t + i n + a d d i t i o n % 2 c + a s f o t a s e + a l f a - t r e a t e d + p a t i e n t s + s h o w e d + a + m a r k e d + i m p r o v e m e n t + i n + p h y s i c a l + f u n c t i o n + a s + m e a s u r e d + b y + t h e + s i x + m i n u t e + w a l k + t e s t % 0 a i n + q 1 % 2 c + c l i n i c a l + d a t a + w e r e + a l s o + p r e s e n t e d + f o r + t h e + f i r s t + t i m e + f r o m + t h e + p h a s e + i i + s t u d y + o f + a s f o t a s e + a l f a + i n + a d o l e s c e n t s + a n d + a d u l t + w i t h + h p p + a t + t h e + a m e r i c a n + c o l l e g e + o f + m e d i c a l + g e n e t i c s + m e e t i n g + i n + m a r c h + i n + t h i s + s t u d y % 2 c + a l l + p a t i e n t s + w e r e + t r e a t e d + w i t h + a s f o t a s e + a l f a % 2 c + h a d + a n + o b j e c t i v e + r e s p o n s e + t o + t h e r a p y + w i t h + c l i n i c a l l y + a n d + s t a t i s t i c a l l y + m e a n i n g f u l + d e c r e a s e s + i n + e n z y m e + s u b s t r a t e + a n d + t h e s e + b i o c h e m i c a l + i m p r o v e m e n t s + w e r e + a c c o m p a n i e d + b y + i m p r o v e m e n t + i n + p a t i e n t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + p h y s i c a l + f u n c t i o n + a s + d e m o n s t r a t e d + b y + a n + i m p r o v e m e n t + i n + t h e + s i x + m i n u t e + w a l k + t e s t % 0 a b a s e d + o n + t h e + s i g n i f i c a n t + a c c o m p l i s h m e n t s + d u r i n g + t h e + f i r s t + q u a r t e r % 2 c + w e + a r e + a c c e l e r a t i n g + t h e + d e v e l o p m e n t + o f + a s f o t a s e + a l f a + a s + a + t r e a t m e n t + f o r + a + b r o a d + s p e c t r u m + o f + h p p + p a t i e n t s + o u r + e f f o r t s + r e m a i n e d + f o c u s e d + o n + t h r e e + k e y + a r e a s % 0 a f i r s t % 2 c + w e + a r e + o p t i m i z i n g + t h e + c o m m e r c i a l + s c a l e + m a n u f a c t u r i n g + p r o c e s s + t o + e n s u r e + o u r + a b i l i t y + t o + p r o v i d e + l o n g - t e r m + s u p p o r t + t o + t h e + h p p + c o m m u n i t y % 0 a s e c o n d % 2 c + w e + a r e + c o m p l e t i n g + t h e + c l i n i c a l + d e v e l o p m e n t + p r o g r a m + i n + c h i l d r e n + p r i o r + t o + a n + a n t i c i p a t e d + r e g u l a t o r y + f i l i n g + f o r + p e d i a t r i c + p a t i e n t s + i n + 2 0 1 4 + w e + w i l l + h a v e + f u r t h e r + d i s c u s s i o n s + w i t h + r e g u l a t o r s + r e g a r d i n g + t h e + s t u d i e s + r e q u i r e d + f o r + r e g i s t r a t i o n + i n + p e d i a t r i c s + a n d + e x p e c t + t o + c o m p l e t e + a + n a t u r a l + h i s t o r y + s t u d y + i n + i n f a n t s + t o + s u p p l e m e n t + t h e + e x i s t i n g + o p e n + l a b e l + t r i a l % 0 a a n d + t h i r d % 2 c + o u r + e x p a n d i n g + a d u l t + p r o g r a m + w i l l + n o w + b e + f u r t h e r + i n f o r m e d + b y + t h e + e n c o u r a g i n g + p h a s e + 2 + d a t a + w e + c o n t i n u e + t o + e x p e c t + t h a t + w e + w i l l + n e e d + t o + i n i t i a t e + a + p l a c e b o - c o n t r o l l e d + s t u d y + i n + a d u l t s + w i t h + s e v e r e + h p p + t o + s u p p o r t + r e g i s t r a t i o n + i n + t h i s + p a t i e n t + p o p u l a t i o n + i + l o o k + f o r w a r d + t o + u p d a t i n g + y o u + o n + o u r + a s f o t a s e + a l f a + p r o g r a m + o n + f u t u r e + c a l l s % 0 a b e y o n d + a c e t a t e + a l p h a % 2 c + w e + a r e + a l s o + e v a l u a t i n g + t h r e e + a d d i t i o n a l + h i g h l y + i n n o v a t i v e + t h e r a p e u t i c s + a s + t r e a t m e n t + f o r + p a t i e n t s + w i t h + s e v e r e + a n d + u l t r a - r a r e + d i s o r d e r s + w e + a r e + p l e a s e d + t h a t + t h e s e + c o v e r + a + w i d e + r a n g e + o f + t h e r a p e u t i c + a r e a s % 2 c + e n a b l i n g + u s + t o + e m p l o y + o u r + s k i l l s + i n + d e v e l o p i n g + u l t r a - o r p h a n + t h e r a p i e s + t o + a + g r o w i n g + u n i v e r s e + o f + p a t i e n t s % 0 a l o o k i n g + b r i e f l y + a t + t h e s e + p r o g r a m s % 2 c + f i r s t % 2 c + i n + o u r + n e w + m e t a b o l i c + d i s e a s e + a r e a % 2 c + w h i c h + i n c l u d e s + a s f o t a s e + a l f a % 2 c + w e + a r e + a l s o + a c c e l e r a t i n g + t h e + d e v e l o p m e n t + o f + o u r + c p m p + r e p l a c e m e n t + t h e r a p y + f o r + t h e + t r e a t m e n t + o f + p a t i e n t s + w i t h + m o l y b d e n u m + c o f a c t o r + d e f i c i e n c y + t y p e + a % 2 c + a + s e v e r e + u l t r a - r a r e + a n d + g e n e t i c + m e t a b o l i c + d i s o r d e r + t h a t + i s + f a t a l + i n + n e w b o r n s % 0 a i n + 2 0 1 1 % 2 c + w e + m a d e + s u b s t a n t i a l + p r o g r e s s + o n + o u r + g m p + m a n u f a c t u r i n g + p r o c e s s + f o r + o u r + c p m p + r e p l a c e m e n t + t h e r a p y + f o l l o w i n g + s u c c e s s f u l + c o m p l e t i o n + o f + t h e + i n i t i a l + c g m p + m a n u f a c t u r i n g + r u n s + a t + t h e + e n d + o f + l a s t + y e a r % 2 c + w e + n o w + h a v e + c o m m e n c e d + p r e - i n d + t o x i c o l o g y + s t u d i e s + a d d i t i o n a l l y % 2 c + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + a l s o + n o w + i n c r e a s i n g + o u r + c p m p + m a n u f a c t u r i n g + t o + p r o v i d e + s u f f i c i e n t + s u p p l i e s + t o + c o m m e n c e + c l i n i c a l + s t u d i e s + i n + e a r l y + 2 0 1 3 % 0 a s e c o n d % 2 c + w e + c o n t i n u e + t o + e n r o l l + p a t i e n t s + i n + a + p h a s e + i + s t u d y + t o + c h a r a c t e r i z e + t h e + m e c h a n i s m + o f + a c t i o n + o f + a l x n 1 1 0 2 + f o r m a l l y + k n o w n + a s + t t 3 0 + a n d + t o + d e v e l o p + i n i t i a l + s a f e t y + d a t a + a s + a + r e m a i n d e r % 2 c + a l x n 1 1 0 2 + i s + a + u n i q u e + i n h i b i t o r + o f + t h e + a l t e r n a t i v e + c o m p l e m e n t + p a t h w a y + w i t h + a + m e c h a n i s m + o f + a c t i o n + d i f f e r e n t + f r o m + s o l i r i s + a n d + t h u s + b u i l d + o n + o u r + w o r l d - c l a s s + e x p e r t i s e + i n + c o m p l e m e n t + b i o l o g y + o n c e + w e + h a v e + t h e + d a t a + f r o m + t h e + s t u d y % 2 c + w e + c a n + b e t t e r + e v a l u a t e + t h e + o v e r a l l + t h e r a p e u t i c + p o t e n t i a l + o f + a l x n 1 1 0 2 % 2 c + f o r + v a r i o u s + d i s e a s e + t a r g e t s % 0 a l a s t l y % 2 c + w e + c o n t i n u e + t o + e n r o l l + s u b j e c t s + i n + a + p h a s e + i + c l i n i c a l + s t u d y + o f + a l x n 1 0 0 7 % 2 c + a + n o v e l + a n t i - i n f l a m m a t o r y + a n t i b o d y % 2 c + w h i c h + i s + a + p r o d u c t + o f + o u r + a n t i b o d y + d i s c o v e r y + t e c h n o l o g i e s + t h i s + p h a s e + i + s t u d y + i s + e v a l u a t i n g + t h e + s a f e t y + t o l e r a b i l i t y + p h a r m a c o k i n e t i c s + a n d + p h a r m a c o d y n a m i c s + o f + t h i s + c o m p o u n d + i n + h e a l t h y + v o l u n t e e r s % 0 a i + w o u l d + l i k e + t o + t u r n + b r i e f l y + t o + t h e + m u l t i - f a c t o r i a l + d i s e a s e + a g e - r e l a t e d + m a c u l a r + d e g e n e r a t i o n + i m p o r t a n t l y % 2 c + e c u l i z u m a b + o r + a m d + d o e s + n o t + f i t + w i t h i n + o u r + c o r e + m i s s i o n + o f + d e v e l o p i n g + l i f e + t r a n s f o r m i n g + t h e r a p i e s + f o r + p a t i e n t s + w i t h + s e v e r e + u l t r a - r a r e + a n d + l i f e - t h r e a t e n i n g + d i s o r d e r s + i + w o u l d + n o t e + t h a t + d a t a + f r o m + t h e + i n v e s t i g a t o r + i n i t i a t e d + s t u d y + o f + i n t r a v e n o u s + e c u l i z u m a b + i n + p a t i e n t s + w i t h + d r y + a m d + w i l l + b e + a v a i l a b l e + a t + t h e + a r v o + c o n f e r e n c e + o n + m a y + 7 t h % 0 a a s + a + r e m a i n d e r % 2 c + t h i s + i s + a n + i n v e s t i g a t o r - i n i t i a t e d + e x p l o r a t o r y + s t u d y + d e s i g n e d + t o + t e s t + t h e + s t o m a c h % 2 c + b u t + n o t + d i r e c t + i n t r a o c u l a r + c o m p l e m e n t + i n h i b i t i o n + i n + p a t i e n t s + w i t h + d r y + a m d + t h e s e + d a t a + w i l l + h e l p + d e t e r m i n e + w h e t h e r + o r + n o t + c o m p l e m e n t + i n h i b i t i o n + p l a y s + a + r o l e + i n + d r y + a m d + w e + e x p e c t + t o + r e v i e w + o u r + o p t i o n s + f o r + t h i s + p r o g r a m + l a t e r + t h i s + y e a r % 0 a i n + c l o s i n g % 2 c + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 m + p r o u d + t h a t + a l e x i o n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + r % 2 6 d + t e a m + c o n t i n u e s + t o + b e + d r i v e n + v i a + p a s s i o n + a n d + a n + u r g e n c y + t o + h e l p + p a t i e n t s + a n d + f a m i l i e s + s u f f e r i n g + w i t h + s e v e r e + a n d + u l t r a - r a r e + d i s o r d e r s + i + l o o k + f o r w a r d + t o + u p d a t i n g + y o u + o n + o u r + p r o g r e s s + o n + f u t u r e + c o n f e r e n c e + c a l l % 0 a i + w i l l + n o w + t u r n + t h e + c a l l + b a c k + t o + l e n n y + l e n n y % 3 f % 0 a l e o n a r d + b e l l % 0 a t h a n k s % 2 c + s t e v e + o u t + s t r o n g + s t a r t + t o + 2 0 1 2 + p o s i t i o n s + u s + t o + k e e p + e x e c u t i n g + r a p i d l y + o n + o u r + k e y + o b j e c t i v e s + t h r o u g h o u t + t h e + y e a r + w e + a r e + p l e a s e d + t h a t + w e + c o n t i n u e + t o + s e r v e + a n + i n c r e a s i n g + n u m b e r + o f + p a t i e n t s + w i t h + p n h + a n d + n o w + a h u s % 2 c + a n d + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + c o n t i n u e + a c c e l e r a t i n g + o u r + d e v e l o p m e n t + p r o g r a m s + w i t h + a + g o a l + o f + r a p i d l y + b r i n i n g + l i f e - t r a n s f o r m i n g + i n n o v a t i o n s + t o + m o r e + p a t i e n t s + w i t h + s e v e r e + a n d + u l t r a - 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