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Glucosuric drugs may help resolve persistent urinary E. Coli infection |
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EurekAlert: Dr. Collins' approach consists of adding sugar to the antibiotic. The sugar acts as a stimulant, essentially turning on normal bacterial responses, such as dying when confronted by a killer antibiotic. Using this strategy on E. coli bacteria, a common cause of urinary tract infections, the team was able to eliminate 99.9 per cent of the persisters within just two hours - compared to no effect without sugar. The approach was similarly effective in killing Staphylococcus aureus bacteria, which cause sometimes deadly staph infections. "Our goal was to improve the effectiveness of existing antibiotics, rather than invent new ones, which can be a long and costly process," says Collins' Boston University colleague, Kyle Allison, who was the first author on the study.
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