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Sodium retention action of thiazolidinediones linked to increased proximal tubular absorption. PDF Print
EurekAlert: Seki's team has found that TZDs also have direct effects on channels in the kidney known as the proximal tubules. TZDs rapidly stimulate sodium-coupled bicarbonate absorption from renal proximal tubules. Inhibitors of PPAR? or other players in the pathway suppress that stimulation, they report.

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