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Why exercise has a beneficial effect on neuropathic pain. |
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EurekAlert: Exercise also led to reduced expression of inflammation-promoting cytokines in sciatic nerve tissue—specifically, tumor necrosis factor-alpha and interleukin-1-beta. That was consistent with previous studies suggesting that inflammation and pro-inflammatory cytokines play a role in the development of neuropathic pain in response to nerve injury. Exercise also led to increased expression of a protein, called heat shock protein-27, which may have contributed to the reductions in cytokine expression.
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