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Dialysis world news


Prof. Dr. Dimitrios Oreopoulos obituary
PDI: The world of nephrology—and peritoneal dialysis (PD) in particular—was diminished with the recent passing of Dimitrios Oreopoulos.

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Do neutrophils mediate insulin resistance in obesity?
EurekAlert: Using liver and fat cells from mice and humans and live mouse models, a team led by Jerrold M. Olefsky, MD, associate dean for scientific affairs at UC San Diego Health Sciences and professor of medicine, discovered that an enzyme secreted by neutrophils called neutrophil elastase (NE) impairs insulin signaling and boosts resistance. Conversely, deletion of NE in obese mice fed a high-fat diet improved insulin sensitivity.

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Is there an obesity paradox in diabetes?
Reuters: Obesity and diabetes might not be the double whammy you'd expect, according to a fresh look at older studies.

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Apoptosis inhibitor fusion protein ensures recovery from acute liver failure in mice.
Science Daily: Now Dr. Donath and his colleagues have fused ARC to a noninfectious fragment of the human immunodeficiency virus (HIV), called TAT for short. The researchers used TAT as a shuttle to transfer this survival-switch construct into the liver. Mice with acute liver failure were given an intravenous or intraperitoneal injection with the construct. "Within just a few minutes the fusion protein TAT-ARC reached the liver of the animals and immediately began to take effect. ARC was able to stop the apoptosis of the liver cells, and all of the animals completely recovered," Dr. Donath said.

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Diacetyl, an artificial butter flavor used in popcorn, linked to Alzheimer's disease worsening.
Science Blog: A new study raises concern about chronic exposure of workers in industry to a food flavoring ingredient used to produce the distinctive buttery flavor and aroma of microwave popcorn, margarines, snack foods, candy, baked goods, pet foods and other products. It found evidence that the ingredient, diacetyl (DA), intensifies the damaging effects of an abnormal brain protein linked to Alzheimer’s disease. The study appears in ACS’ journal Chemical Research in Toxicology.

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