Dialysis world news


Looking away as you get stuck by a needle associated with less pain.
Health Day News: Averting your eyes when you're receiving a shot really may help reduce discomfort, new research suggests.

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Possible risk of sudden death with certain alkalosis-inducing dialysate concentrates.
Renalweb: Evidence is now showing that a significant percentage of dialysis patients have unexpectedly high levels of bicarbonate in their blood and are actually suffering from alkalosis, the opposite of acidosis. The association between higher dialysate bicarbonate levels, pre-dialysis serum bicarbonate levels, and increased mortality was the topic of a presentation at the Annual Meeting of the American Society of Nephrology in November 2011. This problem appears to have been growing virtually unnoticed for many years, but apparently with the increased market share of Granuflo in the US and a lack of clinical knowledge about total buffer levels, more clinical problems have become evident.

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Bedbugs and dialysis units in the news.
WSOC TV: “She usually takes a blanket. She was told not to bring her blanket because they had bedbugs,” Crank said. “I don’t know who has the bugs and who’s bringing them in,” said Chuck Garris, a patient at the facility.

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Short-term azithromycin treatment associated with increased cardiovascular death risk.
EurekAlert: While the absolute number of deaths was quite low, relative to amoxicillin, there were about 47 more deaths per million courses of therapy in those taking the azithromycin. That risk increased to 245 additional cardiovascular deaths per million in patients already known to have a high risk for heart problems. The researchers emphasized that the decision to prescribe any antibiotic requires careful balancing of both potential benefits and risks. This calculation must consider the severity of the infection, the susceptibility of the organism, the availability of alternative antibiotics and adverse effects.

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Study of HDL genetic variants casts doubt on the beneficial impact of higher HDL levels.
EurekAlert: What they found was surprising. Individuals who carried a particular variation in a gene called endothelial lipase had HDL levels that were elevated about 6mg/dl, or 10% — a change expected to decrease heart attack risk by about 13%. However, these individuals showed no difference in their risk of heart disease compared to people without the variant. Similarly, the researchers identified a panel comprised of not just one but 14 different HDL-raising variants. They devised a scoring system based on the total number of copies of the gene variants a person carries — ranging from 0 to 28 — and then asked whether that score relates to the risk of heart attack. Here also they uncovered no association.

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